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All Muslim nations are dangerous to be a Christian in, but none like Somalia. The violence against Christians there is so bad that according to a recent ...

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Cannabinoid physiology and pharmacology: 30 years of progress

Abstract

9-Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528, through G-protein-coupled receptors, CB1 in the brain, and CB2 in the immune system. Eicosanoids anandamide and 2-arachidonoylglycerol are the “endocannabinoid” agonists for these receptors. CB1 receptors are abundant in basal ganglia, hippocampus and cerebellum, and their functional activity can be mapped during behaviors using cerebral metabolism as the neuroimaging tool. CB1 receptors couple to Gi/o to inhibit cAMP production, decrease Ca2+ conductance, increase K+ conductance, and increase mitogen-activated protein kinase activity. Functional activation of G-proteins can be imaged by [35S]GTP?S autoradiography. Post-synaptically generated endocannabinoids form the basis of a retrograde signaling mechanism referred to as depolarization-induced suppression of inhibition (DSI) or excitation (DSE). Under circumstances of sufficient intracellular Ca2+ (e.g., burst activity in seizures), synthesis of endocannabinoids releases a diffusible retrograde messenger to stimulate presynaptic CB1 receptors. This results in suppression of ?-aminobutyric acid (GABA) release, thereby relieving the post-synaptic inhibition. Tolerance develops as neurons adjust both receptor number and cellular signal transduction to the chronic administration of cannabinoid drugs. Future therapeutic drug design can progress based upon our current understanding of the physiology and pharmacology of CB1, CB2 and related receptors. One very important role for CB1 antagonists will be in the treatment of craving in the disease of substance abuse.

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I Can Orgasm Without My Genitals Being Touched — Am I A Freak?

Hey Refinery29,

The other night, something embarrassing happened. I jizzed my pants. Well, the female equivalent of it. There's this guy named Sean who I've had sexual tension with for years. Like, you could cut it with a knife. Up until recently, we've just been good friends with an unspoken desire to fuck each other's brains out. Simply sitting next to him in public gets me wet. Anyway, the other night he finally came home with me. We were making out on my couch, and I was sitting on his lap. I came. I mean, I came before we even really got to foreplay, let alone sex. His hands weren't even on my clit. This has happened to me once or twice before in my life. I'll be in a sexual situation and be so turned on that I'll have an orgasm before anything even happens below the belt. Usually, I just try to pretend like it didn't happen and continue hooking up (like I did recently with Sean), because coming this quickly seems a little embarrassing.

I realize that may sound like every woman's dream, and is a shitty thing to complain about when a lot of women can't have an orgasm at all, but I have to ask: Is this normal or am I a freak?

Sincerely,

Captain Comes In Her Pants

Dear Captain Comes In Her Pants,

If you're a freak, I'm a freak. Not too long ago, something similar happened to me. I was at a play (sex) party, so I had been around public sex for literally hours — which means I was very horny. As the party was winding down, I hooked up with a woman I met earlier in the night. We first began chatting about art and hit it off right away. But since I felt like a socially awkward teenager in her presence, I hid from her for a lot of the party. I was so attracted to her, it was as if I made her up in my head. I thought our sexual tension would cause the place to explode should we act on it.

I remember thinking, "I can't talk to this person, because I'm going to jizz myself the second she touches me." I was right. She grabbed my hand and led me to a bed. We made out for a long time, but never took off our underwear — and I came from dry humping alone. She wasn't even rubbing my clit! We were just making out and gyrating, and all of a sudden I felt an orgasm coming and thought, "Oh shit." I came and (like you) was a little embarrassed.

Granted, dry humping does involve some genital stimulation, so it's not a perfect parallel to your story. But I usually need intense direct clitoral stimulation with a hand or vibrator to get off. So, after I came, I told my new friend, "Oh my god, I came already. You must be magic." And honestly, she just seemed super flattered, and we continued hooking up.

While I understand your mortification, there's no reason to feel embarrassed. Many straight men, in particular, are obsessed with wanting to get women off, since it makes them feel like they're good in bed. And being good in bed can be an incredible ego boost (for anyone, not just straight men). Should this happen again with Sean, I think it's a great idea to tell him that he made you come so quickly — he'll be flattered. And since people with vaginas are capable of multiple orgasms, after you tell him and continue hooking up, you could even come again.

To make sure that we're not just both freaks, I asked a doctor if it's normal to come without direct genital stimulation. She has good news: We're normal! "There have been studies that show orgasm can be reached without necessarily directly stimulating the genitals," says Jessica Shepherd, MD, an Ob/Gyn at the University of Illinois at Chicago. "This is much more common in women and not often seen in men." The reason humans have this mystical ability is because the brain is the most powerful sex organ, Dr. Shepherd says. That's why you could come just by making out and sitting on Sean's lap after what sounds like literally years of fantasizing about him. It's also why I was able to have an orgasm while making out and gyrating with the woman of my dreams, even though I usually need much more than that to get off. Our brains were so aroused that our genitals climaxed like the chorus in a Katy Perry song.

And you're right: Some women have anorgasmia and can't reach orgasm at all. So I'd say you should consider your unexpected orgasms divine blessings, not sources for embarrassment. Also, it's worth mentioning that some women can come simply from nipple stimulation, so if your partner was fondling your breasts or nipples, that may have also contributed to your serendipitous orgasm.

So no, you're not a freak. Well, you might be, but that's a good thing.

Love,

Sophie

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Men risk their lives in wars so women can enjoy societies where they can pursue feminist goals, such as punishing men for sexist language.

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Three human traffickers who fooled women into prostitution in Dubai are jailed

The National

DUBAI // Three men who persuaded two maids to run away from their sponsor before selling them into the sex industry have been jailed for five years each.

The Bangladeshis were convicted of trafficking the two Indonesian women, a charge they denied in August.

One 33-year-old victim told Dubai Criminal Court that she and the other maid were encouraged to flee their sponsor’s home in Ras Al Khaimah after five months in the UAE.

They were taken by one of the men to a hotel in RAK, where they spent the night before heading to Dubai.

"They took me to a flat in Dubai where I was sold for Dh4,000 and told I have to work in prostitution," said the woman, who was locked up and assaulted when she refused.

She was forced to have sex with different men against her will, including one of the defendants, and escaped when she fell ill and was taken to a hospital.

"They gave me Dh500 for my treatment, which I used to hail a cab and head to a police station," she said.

The second victim, 42, said her compatriot made arrangements with the defendants to run away from their sponsor without knowing they would be sold into the sex industry.

"We were both locked up after we refused to prostitute ourselves, but two days later I managed to run away while the man who was keeping guard of the flat fell asleep," said the maid, who also went to the police.

The incident took place in June 2015 but the defendants were arrested in March last year.

A 35-year-old receptionist said he saw the men at the hotel in RAK where they booked four rooms.

"This was not the first time I saw one of the men. He had been a regular guest for over six years and every time he checks in, he comes with different women," said the Indian.

Prosecutors said the men confessed to trafficking during investigations but they denied the charges in court.

They will all be deported after serving their prison terms.

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